Ammonia → 2-(2,6-Dichlorophenyl)-2h-pyrazolo[4,3-c]pyridin-4-amine

関与物質

反応手順

Following the procedure described for N-[2-(2,6-dichlorophenyl)-2H-pyrazolo[4,3-c]pyridine-4-yl]-N′-methylpyrimidine-4,6-diamine, 4-chloro-2-(2,6-dichlorophenyl)-2H-pyrazolo[4,3-c]pyridine and 33% aqueous ammonia (1.5 mL) were reacted to afford the title compound as a white solid (139 mg, 53% yield). 1H NMR (400 MHz, DMSO-d6): δ 8.66 (d, J=0.9 Hz, 1H), 7.79-7.77 (m, 2H), 7.67 (dd, J=9.0, 7.3 Hz, 1H), 7.58 (d, J=6.5 Hz, 1H), 7.10 (br s, 2H), 6.74 (dd, J=6.5, 1.0 Hz, 1H). LCMS (Method B): RT=2.54 min, m/z: 279 [M+H+].

情報源と証拠