4-Bromo-2-(2,6-dichloro-4-nitrophenyl)-7-fluoro-2H-pyrazolo[4,3-c]pyridine → 2-(4-Bromo-7-fluoropyrazolo[4,3-c]pyridin-2-yl)-3-chloro-5-nitrobenzonitrile
反応式
[Br:1][C:2]1[C:7]2=[CH:8][N:9]([C:11]3[C:16](Cl)=[CH:15][C:14]([N+:18]([O-:20])=[O:19])=[CH:13][C:12]=3[Cl:21])[N:10]=[C:6]2[C:5]([F:22])=[CH:4][N:3]=1.ClC1C(N2C=C3C(Cl)=NC=C(F)C3=N2)=C(C=C([N+]([O-])=O)C=1)[C:27]#[N:28]>>[Br:1][C:2]1[C:7]2=[CH:8][N:9]([C:11]3[C:12]([Cl:21])=[CH:13][C:14]([N+:18]([O-:20])=[O:19])=[CH:15][C:16]=3[C:27]#[N:28])[N:10]=[C:6]2[C:5]([F:22])=[CH:4][N:3]=1参加物
3
反応条件
- 温度
- 100 °C
実験手順
Following the procedure described for 4-bromo-2-(2,6-dichloro-4-nitrophenyl)-7-fluoro-2H-pyrazolo[4,3-c]pyridine, 3-chloro-2-(4-chloro-7-fluoropyrazolo[4,3-c]pyridin-2-yl)-5-nitrobenzonitrile was heated at 100° C. overnight to afford the title compound as a pale yellow solid (1.38 g, 83% yield). LCMS (Method C): RT=3.62 min, m/z: 396 [M+H+].
出典と根拠
- ORDレコード
- ord-529384bd491f4688a20840bad1179880
- 出典データセット
- uspto-grants-2016_04
- 特許番号
- US09309240B2
反応ノート
読み込み中…