Hydrochloric Acid → Methyl 4-hydroxypiperidine-4-carboxylate

HRID 626964ノート

反応式

HRID 626964 の反応式
Cl.[OH:2][C:3]1([C:9]([OH:11])=[O:10])[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1.Cl.[CH3:13]O>>[OH:2][C:3]1([C:9]([O:11][CH3:13])=[O:10])[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 533992144-Hydroxypiperidine-4-carboxylic acid--hydrogen chloride (1/1)

生成物 1

HCID 21093366Methyl 4-hydroxypiperidine-4-carboxylate

実験手順

4-Hydroxy-4-piperidinecarboxylic acid hydrochloride salt (1 g, 5.1 mmol) was added to a 2% hydrochloric acid solution in methanol (25 mL) and the mixture was stirred at room temperature overnight. The solvent was removed under reduced pressure to give the title compound as the hydrochloride salt (1 g, 92%) as a white solid. δH (400 MHz, DMSO-d6) 9.06 (broad, 2H), 5.89 (broad, 1H), 3.68 (m, 3H), 3.14 (m, 2H), 3.02 (m, 2H), 2.07 (m, 2H), 1.79 (m, 2H).

後処理

  1. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-9bec0bbae83847e2abd67b15afc1fc2d
出典データセット
uspto-grants-2016_04
特許番号
US09309243B2

反応ノート

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