Hydrochloric Acid → (S)-methyl 2-(2-amino-4-methylpentanamido)acetate hydrochloride

HRID 62709ノート

反応式

HRID 62709 の反応式
C(OC([NH:8][C@@H:9]([CH2:18][CH:19]([CH3:21])[CH3:20])[C:10]([NH:12][CH2:13][C:14]([O:16][CH3:17])=[O:15])=[O:11])=O)(C)(C)C.[ClH:22]>O1CCOCC1>[ClH:22].[NH2:8][C@@H:9]([CH2:18][CH:19]([CH3:21])[CH3:20])[C:10]([NH:12][CH2:13][C:14]([O:16][CH3:17])=[O:15])=[O:11]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 6560406methyl 2-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-4-methylpentanamido]acetate

生成物 1

HCID 18603049(S)-methyl 2-(2-amino-4-methylpentanamido)acetate hydrochloride

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

実験手順

To a solution of (S)-methyl 2-(2-((tert-butoxycarbonyl)amino)-4-methylpentanamido) acetate (3w) in 1,4-dioxane was added a 5M solution of HCl in 1,4-dioxane at room temperature. The reaction was stirred at room temperature for 16 h. The reaction mixture was filtered to afford (S)-methyl 2-(2-amino-4-methylpentanamido)acetate hydrochloride (4w) as the filtered solid.

後処理

  1. filtrationThe reaction mixture was filtered

出典と根拠

ORDレコード
ord-3fac7b9d471e44748fbe1c0c04b75aca
出典データセット
uspto-grants-2016_09
特許番号
US09447030B2

反応ノート

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