(2S,5R)-tert-butyl 5-(N-(allyloxy)-2-nitrophenylsulfonamido)-2-(hydroxymethyl)-3-methyl-5,6-dihydropyridine-1(2H)-carboxylate → (2S,5R)-tert-butyl 5-(N-(allyloxy)-2-nitrophenylsulfonamido)-2-(hydroxymethyl)-3-isopropyl-5,6-dihydropyridine-1(2H)-carboxylate

HRID 627134

反応式

HRID 627134 の反応式
C(ON([C@H]1CN(C(OC(C)(C)C)=O)[C@H](CO)C(C)=C1)S(C1C=CC=CC=1[N+]([O-])=O)(=O)=O)C=C.[CH2:34]([O:37][N:38]([C@H:51]1[CH2:56][N:55]([C:57]([O:59][C:60]([CH3:63])([CH3:62])[CH3:61])=[O:58])[C@H:54]([CH2:64][O:65][Si](C(C)(C)C)(C)C)[C:53]([CH:73]([CH3:75])[CH3:74])=[CH:52]1)[S:39]([C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][C:43]=1[N+:48]([O-:50])=[O:49])(=[O:41])=[O:40])[CH:35]=[CH2:36]>>[CH2:34]([O:37][N:38]([C@H:51]1[CH2:56][N:55]([C:57]([O:59][C:60]([CH3:61])([CH3:62])[CH3:63])=[O:58])[C@H:54]([CH2:64][OH:65])[C:53]([CH:73]([CH3:75])[CH3:74])=[CH:52]1)[S:39]([C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][C:43]=1[N+:48]([O-:50])=[O:49])(=[O:41])=[O:40])[CH:35]=[CH2:36]

参加物

3

反応物 2

HCID 89852407(2S,5R)-tert-butyl 5-(N-(allyloxy)-2-nitrophenylsulfonamido)-2-(hydroxymethyl)-3-methyl-5,6-dihydropyridine-1(2H)-carboxylateHCID 89852426(2S,5R)-tert-butyl 5-(N-(allyloxy)-2-nitrophenylsulfonamido)-2-((tert-butyldimethylsilyloxy)methyl)-3-isopropyl-5,6-dihydropyridine-1(2H)-carboxylate2 回

生成物 1

HCID 89852457(2S,5R)-tert-butyl 5-(N-(allyloxy)-2-nitrophenylsulfonamido)-2-(hydroxymethyl)-3-isopropyl-5,6-dihydropyridine-1(2H)-carboxylate収率 87.2%

実験手順

(2S,5R)-tert-butyl 5-(N-(allyloxy)-2-nitrophenylsulfonamido)-2-(hydroxymethyl)-3-isopropyl-5,6-dihydropyridine-1(2H)-carboxylate (660 mg, 87%) was prepared a similar manner as described in Intermediate 81 as a yellow oil, using (2S,5R)-tert-butyl 5-(N-(allyloxy)-2-nitrophenylsulfonamido)-2-((tert-butyldimethylsilyloxy)methyl)-3-isopropyl-5,6-dihydropyridine-1(2H)-carboxylate (Intermediate 91, 0.928 g, 1.48 mmol) as a starting material.

出典と根拠

ORDレコード
ord-0f1e03691b564dcfa0111c3558001947
出典データセット
uspto-grants-2016_04
特許番号
US09309245B2

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