HCID 89852058、化合物 → (3R,6S)-3-(allyloxyamino)-6-(methoxymethyl)-1,2,3,6-tetrahydro-pyridine-4-carboxamide

HRID 627147ノート

反応式

HRID 627147 の反応式
[CH2:1]([O:4][N:5]([C@@H:18]1[C:23]([C:24]([NH2:26])=[O:25])=[CH:22][C@@H:21]([CH2:27][O:28][CH3:29])[NH:20][CH2:19]1)S(C1C=CC=CC=1[N+]([O-])=O)(=O)=O)[CH:2]=[CH2:3].C(ON[C@@H]1C(C(N)=O)=C[C@@H](CO[Si](C(C)(C)C)(C)C)NC1)C=C.C(ON([C@@H]1C(C(N)=O)=C[C@@H](CO[Si](C(C)(C)C)(C)C)NC1)S(C1C=CC([N+]([O-])=O)=CC=1[N+]([O-])=O)(=O)=O)C=C>>[CH2:1]([O:4][NH:5][C@@H:18]1[C:23]([C:24]([NH2:26])=[O:25])=[CH:22][C@@H:21]([CH2:27][O:28][CH3:29])[NH:20][CH2:19]1)[CH:2]=[CH2:3]

参加物

4

反応物 3

HCID 89852058HCID 89852058、化合物2 回HCID 89852509(3R,6S)-3-(N-(allyloxy)-2,4-dinitrophenylsulfonamido)-6-((tert-butyldimethylsilyloxy)methyl)-1,2,3,6-tetrahydropyridine-4-carboxamideHCID 89852545(3R,6S)-3-(allyloxyamino)-6-((tert-butyldimethylsilyloxy)methyl)-1,2,3,6-tetrahydropyridine-4-carboxamide

生成物 1

HCID 89852143(3R,6S)-3-(allyloxyamino)-6-(methoxymethyl)-1,2,3,6-tetrahydro-pyridine-4-carboxamide

実験手順

This intermediate was prepared from (3R,6S)-3-(N-(allyloxy)-2-nitrophenylsulfonamido)-6-(methoxymethyl)-1,2,3,6-tetrahydropyridine-4-carboxamide (Intermediate 113, 734 mg, 1.36 mmol) using the same procedure and isolation techniques to prepare Intermediate 107 from Intermediate 106. The title compound was an orange oil (173 mg, 53%).

出典と根拠

ORDレコード
ord-6c1b09798cf74edfa03c45a290077c0a
出典データセット
uspto-grants-2016_04
特許番号
US09309245B2

反応ノート

読み込み中…