Benzyl Bromide → Methyl 4-(benzyloxy)-3,5-dichlorobenzoate

HRID 62715

反応式

HRID 62715 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([Cl:13])[C:11]=1[OH:12])[C:5]([O:7][CH3:8])=[O:6].[CH2:14](Br)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[CH2:14]([O:12][C:11]1[C:2]([Cl:1])=[CH:3][C:4]([C:5]([O:7][CH3:8])=[O:6])=[CH:9][C:10]=1[Cl:13])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

参加物

3

反応物 2

HCID 7498Benzyl BromideHCID 76856Methyl 3,5-dichloro-4-hydroxybenzoate

生成物 1

HCID 16749549Methyl 4-(benzyloxy)-3,5-dichlorobenzoate収率 120.2%

実験手順

Crude methyl 4-(benzyloxy)-3,5-dichlorobenzoate (2) (16.9 g) was prepared from methyl 3,5-dichloro-4-hydroxybenzoate (1) (10 g, 45.2 mmol) and benzyl bromide (15.5 g, 90 mmol) using a procedure essentially the same as in Step (i) for AAA-001, except that the mixture was stirred at RT for 18 h. The crude product was partially purified by silica gel chromatography (330 g, 0-10% EtOAc/isohexane) to afford a white solid. The material was used in the next step without further purification.

後処理

  1. customThe crude product was partially purified by silica gel chromatography (330 g, 0-10% EtOAc/isohexane)
  2. customto afford a white solid
  3. customThe material was used in the next step without further purification

出典と根拠

ORDレコード
ord-8982104951f8447b8eca71fca4c57db6
出典データセット
uspto-grants-2016_09
特許番号
US09447028B2

関連ノート

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