Methyl 3-chloro-4,5-bis(cyclopentyloxy)benzoate → 3-Chloro-4,5-bis(cyclopentyloxy)benzoic acid
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([O:18][CH:19]2[CH2:23][CH2:22][CH2:21][CH2:20]2)[C:11]=1[O:12][CH:13]1[CH2:17][CH2:16][CH2:15][CH2:14]1)[C:5]([O:7]C)=[O:6]>O1CCOCC1>[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([O:18][CH:19]2[CH2:20][CH2:21][CH2:22][CH2:23]2)[C:11]=1[O:12][CH:13]1[CH2:14][CH2:15][CH2:16][CH2:17]1)[C:5]([OH:7])=[O:6]参加物
3
実験手順
3-Chloro-4,5-bis(cyclopentyloxy)benzoic acid (5) (380 mg, 99%) was prepared from methyl 3-chloro-4,5-bis(cyclopentyloxy)benzoate (4) (400 mg, 1.18 mmol) using a procedure essentially the same as in Step (ii) for AAA-001, except that 1,4-dioxane (10 mL) was used instead of THF: m/z 323 [M−H]− (ES−); 1H NMR (400 MHz, DMSO-d6) δ: 13.07 (1H, br s), 7.52 (1H, d), 7.45 (1H, d), 4.97-4.91 (2H, m), 1.99-1.90 (2H, m), 1.70-1.57 (14H, m).
出典と根拠
- ORDレコード
- ord-bc56ca8647424c439b0877a6aceb0b33