Methyl 5-(2,2-difluoroethoxy)-3-methylpyrazine-2-carboxylate → 5-(2,2-Difluoroethoxy)-3-methylpyrazine-2-carboxylic acid

HRID 627705ノート

反応式

HRID 627705 の反応式
[F:1][CH:2]([F:16])[CH2:3][O:4][C:5]1[N:6]=[C:7]([CH3:15])[C:8]([C:11]([O:13]C)=[O:12])=[N:9][CH:10]=1>Cl.O1CCOCC1>[F:16][CH:2]([F:1])[CH2:3][O:4][C:5]1[N:6]=[C:7]([CH3:15])[C:8]([C:11]([OH:13])=[O:12])=[N:9][CH:10]=1

参加物

4

反応物 1

HCID 86728150Methyl 5-(2,2-difluoroethoxy)-3-methylpyrazine-2-carboxylate

生成物 1

HCID 867281515-(2,2-Difluoroethoxy)-3-methylpyrazine-2-carboxylic acid収率 100%

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 312751,4-Dioxane溶媒

実験手順

A mixture of methyl 5-(2,2-difluoroethoxy)-3-methylpyrazine-2-carboxylate (63.8 mg, 0.275 mmol) in aqueous 2N HCl (1 mL) and Dioxane (2 mL) was stirred at ambient temperature for 20 hrs. The reaction was concentrated and the resulting solid was rinsed with acetonitrile. The filtrate was collected and concentrated in vacuo to give the title compound (60 mg, 0.275 mmol, 100%) as a white solid. MS m/z=219.1 (M+H).

後処理

  1. concentrationThe reaction was concentrated
  2. washthe resulting solid was rinsed with acetonitrile
  3. customThe filtrate was collected
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-adc4f4ef645c432a88f34d06c3fca6ee
出典データセット
uspto-grants-2016_04
特許番号
US09309263B2

反応ノート

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