Ethyl orthoformate → 7-(trifluoromethyl)pyrido[3,2-d]pyrimidin-4(3H)-one
反応式
[NH2:1][C:2]1[C:3]([C:12]([NH2:14])=[O:13])=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.[CH:15](OCC)(OCC)OCC>>[F:10][C:8]([F:11])([F:9])[C:6]1[CH:5]=[N:4][C:3]2[C:12](=[O:13])[NH:14][CH:15]=[N:1][C:2]=2[CH:7]=1参加物
3
反応条件
- 温度
- 120 °C
実験手順
A vial was charged with 3-amino-5-(trifluoromethyl)picolinamide (615 mg, 3.00 mmol) and triethyl orthoformate (2496 μl, 14.99 mmol). The vial was sealed and the mixture was heated at 120° C. for 17 h. Upon cooling, the heterogeneous mixture was filtered and the solids were washed with heptane. 7-(trifluoromethyl)pyrido[3,2-d]pyrimidin-4(3H)-one (540 mg, 2.51 mmol, 84% yield) was isolated as a tan solid. LC/MS (ESI) m/z=216.0 (M+H).
後処理
- customThe vial was sealed
- temperatureUpon cooling
- filtrationthe heterogeneous mixture was filtered
- washthe solids were washed with heptane
出典と根拠
- ORDレコード
- ord-8eafaf9f7c5243cabd304f18f72d432b
- 出典データセット
- uspto-grants-2016_04
- 特許番号
- US09309263B2
反応ノート
読み込み中…