Cesium carbonate → HCID 86728162、化合物
反応式
[Cl:1][C:2]1[N:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][C:8]([OH:12])=[CH:7]2.Br[C:14]#[C:15][CH2:16][CH3:17].C(=O)([O-])[O-].[Cs+].[Cs+]>CN(C=O)C>[CH2:14]([O:12][C:8]1[CH:9]=[N:10][C:11]2[C:6]([CH:7]=1)=[CH:5][CH:4]=[N:3][C:2]=2[Cl:1])[C:15]#[C:16][CH3:17]参加物
5
反応条件
- 温度
- 50 °C
実験手順
To a solution of 8-chloro-1,7-naphthyridin-3-ol (618 mg, 3.42 mmol) in DMF (11 ml) were added bromobutyne (882 mg, 6.67 mmol), cesium carbonate (3233 mg, 9.92 mmol). The reaction mixture was heated at 50° C. for 0.5 h. It was quenched with water, and light brown precipitate was formed. It was then collected by Buchner funnel to yield 3-(but-2-yn-1-yloxy)-8-chloro-1,7-naphthyridine (550 mg, 74% yield) as light brown solid. MS m/z: 233.1 [M+H].
後処理
- customIt was quenched with water
- customlight brown precipitate was formed
- customIt was then collected by Buchner funnel
出典と根拠
- ORDレコード
- ord-67ca08232d714574a205f393f43ea89b
- 出典データセット
- uspto-grants-2016_04
- 特許番号
- US09309263B2
反応ノート
読み込み中…