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Morpholine → 7-Hydroxyisoflavone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Morpholine | HCID 8083 | — |
| 反応物 | Ethylorthoformate | HCID 53630039 | — |
| 反応物 | 2,4-Dihydroxy-phenyl-benzyl-ketone | HCID 54014987 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 7-Hydroxyisoflavone | HCID 5376891 | 90.6% |
反応手順
A mixture of 20 g (0.0877 mole) 2,4-dihydroxy-phenyl-benzyl-ketone, 20.7 g (0.14 mole) ethyl-orthoformate and 1 ml of morpholine is stirred on a hot water bath. Crystallization starts after heating for 25 minutes. The inert temperature falls back to 87° C. from 96° C. during the reaction. After stirring for 5 hours the reaction mixture is diluted with 48 ml of chloroform and then one may proceed as disclosed in Example 5. 18.9 g of 7-hydroxy-isoflavone are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05247102 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-90f5082eeee942519d56cfae78d6b65a |
| 出典メモ | uspto-grants-1993_09 |