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Dicyclohexylcarbodiimide → 2-(2-Dodecanoylamino-3-hydroxybutanoylamino)-3-hydroxybutanoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Methyl 2-amino-3-hydroxybutanoate | HCID 324007 | — |
| 反応物 | 2-Dodecanoylamino-3-hydroxybutanoic acid | HCID 9879439 | — |
| 生成物 | 2-(2-Dodecanoylamino-3-hydroxybutanoylamino)-3-hydroxybutanoic acid | HCID 23132027 | 50.9% |
反応手順
2-Dodecanoylamino-3-hydroxybutanoic acid (15.07 g) and 2-amino-3-hydroxybutanoic acid methyl ester (6.66 g) were condensed with dicyclohexylcarbodiimide (10.31 g). Thereafter, methyl ester was hydrolyzed with sodium hydroxide to give 2-(2-dodecanoylamino-3-hydroxybutanoylamino)-3-hydroxybutanoic acid (10.24 g). The structure thereof was identified by 1H-NMR (400 MHz, CD3OD, r.t.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09309486B2 |
| 出典データセット | uspto-grants-2016_04 |
| ORD ID | ord-ce3ddd5890474d97b0bb179d4da7e76c |
| 出典メモ | uspto-grants-2016_04 |