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Dimethylformamide → 7-Hydroxyisoflavone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Morpholine | HCID 8083 | — |
| 反応物 | Ethylorthoformate | HCID 53630039 | — |
| 反応物 | 2,4-Dihydroxy-phenyl-benzyl-ketone | HCID 54014987 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 7-Hydroxyisoflavone | HCID 5376891 | 90.5% |
反応手順
A mixture of 100 kg (438.5 mole) of 2,4-dihydroxy-phenyl-benzyl-ketone, 38 kg of dimethyl-formamide, 5.2 kg of morpholine and 75 kg (506 mole) of ethyl-orthoformate is stirred at 80°-90° C., while within one hour crystallization is initiated. 360 kg of chloroform are added to the suspension after 7 hours at 60° C. After cooling the crystalline substance is centrifuged, covered with chloroform, filtered and dried. 94.5 kg of 7-hydroxy-isoflavone are obtained, 7-ethoxy-isoflavone content: 0.1% by weight, yield: 90.5%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05247102 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-e89dd36c6e3b43d29e69f02bfcdffabb |
| 出典メモ | uspto-grants-1993_09 |