Methylamine → 3-chloro-4-(3-(4,5-dihydrobenzo[b]thieno[2,3-d]oxepin-2-yl)-4H-1,2,4-triazol-4-yl)-N-methylbenzamide
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[N:11]1[CH:15]=[N:14][N:13]=[C:12]1[C:16]1[S:29][C:19]2[C:20]3[CH:28]=[CH:27][CH:26]=[CH:25][C:21]=3[O:22][CH2:23][CH2:24][C:18]=2[CH:17]=1)[C:5]([OH:7])=O.[CH3:30][NH2:31]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[N:11]1[CH:15]=[N:14][N:13]=[C:12]1[C:16]1[S:29][C:19]2[C:20]3[CH:28]=[CH:27][CH:26]=[CH:25][C:21]=3[O:22][CH2:23][CH2:24][C:18]=2[CH:17]=1)[C:5]([NH:31][CH3:30])=[O:7]参加物
3
実験手順
3-Chloro-4-(3-(4,5-dihydrobenzo[b]thieno[2,3-d]oxepin-2-yl)-4H-1,2,4-triazol-4-yl)benzoic acid and methylamine were reacted by a procedure similar to that to prepare 137 in Example 47 to give 209. MS: (ESI+) 437.1
後処理
- customthat to prepare 137 in Example 47