Fenipentol → (1-Bromopentyl)benzene

HRID 628264ノート

反応式

HRID 628264 の反応式
P(Br)(Br)[Br:2].[C:5]1([CH:11](O)[CH2:12][CH2:13][CH2:14][CH3:15])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>CCOCC>[Br:2][CH:11]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH2:12][CH2:13][CH2:14][CH3:15]

参加物

4

反応物 2

HCID 3338FenipentolHCID 24614Phosphorus tribromide

生成物 1

HCID 10900349(1-Bromopentyl)benzene

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

PBr3 (0.171 mL, 1.82 mmol, Aldrich) was added to a solution of 1-phenylpentan-1-ol (0.500 g, 3.04 mmol, Alfa Aesar) in Et2O (3.2 mL) at 0° C. The reaction was allowed to reach ambient temperature and then was quenched with ice water and diluted with hexanes. The layers were separated and the organic layer was washed with water and then with brine, dried over sodium sulfate, filtered and concentrated. Flash chromatography, eluting with hexanes afforded product (0.15 g, 22%).

後処理

  1. customto reach ambient temperature
  2. customwas quenched with ice water
  3. additiondiluted with hexanes
  4. customThe layers were separated
  5. washthe organic layer was washed with water
  6. dry with materialwith brine, dried over sodium sulfate
  7. filtrationfiltered
  8. concentrationconcentrated
  9. washFlash chromatography, eluting with hexanes afforded product (0.15 g, 22%)

出典と根拠

ORDレコード
ord-48cca4ff248444dc9b37fc291373a27a
出典データセット
uspto-grants-2016_04
特許番号
US09309246B2

反応ノート

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