3-(4-Hydroxyphenyl)propionic acid → Benzenepropanoic acid, 4-hydroxy-, methyl ester

HRID 62838

反応式

HRID 62838 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]([OH:12])=[O:11])=[CH:4][CH:3]=1.Cl.O1CCOC[CH2:15]1>CO>[CH3:15][O:11][C:10](=[O:12])[CH2:9][CH2:8][C:5]1[CH:4]=[CH:3][C:2]([OH:1])=[CH:7][CH:6]=1

参加物

4

反応物 2

HCID 103943-(4-Hydroxyphenyl)propionic acidHCID 204431481,4-Dioxane hydrochloride

生成物 1

HCID 79706Benzenepropanoic acid, 4-hydroxy-, methyl ester収率 100.5%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

After 3-(4-hydroxy-phenyl)propionic acid (3 g, 18 mmol) was added with MeOH (6 mL), 4M HCl/dioxane solution (18 mL, 72 mmol) was added thereto, and the mixture was stirred at room temperature for 3 hours. The reactant was concentrated, added with EtOAc, and then washed with NaCl aqueous solution. The organic layer was separated, dried with MgSO4, and filtered to obtain the title compound (3.26 g, 99%).

後処理

  1. additionwas added
  2. concentrationThe reactant was concentrated
  3. additionadded with EtOAc
  4. washwashed with NaCl aqueous solution
  5. customThe organic layer was separated
  6. dry with materialdried with MgSO4
  7. filtrationfiltered

出典と根拠

ORDレコード
ord-ec3f833bd73143d4a3ef43c7709226b4
出典データセット
uspto-grants-2016_09
特許番号
US09447044B2

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