Benzyl Bromide → 1-(Benzyloxy)-4-bromo-2-fluorobenzene

HRID 62841

反応式

HRID 62841 の反応式
C([O-])([O-])=O.[K+].[K+].[CH2:7](Br)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[Br:15][C:16]1[CH:21]=[CH:20][C:19]([OH:22])=[C:18]([F:23])[CH:17]=1>CN(C=O)C>[CH2:7]([O:22][C:19]1[CH:20]=[CH:21][C:16]([Br:15])=[CH:17][C:18]=1[F:23])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

参加物

5

反応物 3

HCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 27249814-Bromo-2-fluorophenol

生成物 1

HCID 187574911-(Benzyloxy)-4-bromo-2-fluorobenzene収率 101.1%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

DMF (12 mL), K2CO3(1.19 g, 8.55 mmol) and benzyl bromide (0.75 mL, 6.27 mmol) was added to 4-bromo-2-fluorophenol (1.1 g, 5.7 mmol), and the mixture was stirred at room temperature for 2 hours. After the termination of the reaction, the reactant was concentrated and the residue was diluted with 20 mL water. The mixture was extracted with EtOAc. The organic layer was separated and dried with MgSO4 to obtain the title compound (1.62 g, 100%).

後処理

  1. customAfter the termination of the reaction
  2. concentrationthe reactant was concentrated
  3. additionthe residue was diluted with 20 mL water
  4. extractionThe mixture was extracted with EtOAc
  5. customThe organic layer was separated
  6. dry with materialdried with MgSO4

出典と根拠

ORDレコード
ord-02bc1bb165664703bc47e99c5b59c704
出典データセット
uspto-grants-2016_09
特許番号
US09447044B2

関連ノート

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