2-(Difluoromethoxy)-6-nitrotoluene → 3-(Difluoromethoxy)-2-methylaniline
反応式
[F:1][CH:2]([F:14])[O:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([N+:10]([O-])=O)[C:5]=1[CH3:13]>[C].[Pd].C(O)C>[F:1][CH:2]([F:14])[O:3][C:4]1[C:5]([CH3:13])=[C:6]([CH:7]=[CH:8][CH:9]=1)[NH2:10]参加物
4
実験手順
A mixture of the above-prepared 1-difluoromethoxy-2-methyl-3-nitrobenzene (described in Reference Preparation example 3) 7.50 g, palladium-carbon (palladium 5%) 0.8 g and ethanol 80 ml was stirred at room temperature under hydrogen atmosphere for eight hours. The reaction mixture was filtered and the filtrate was concentrated to give 3-difluoromethoxy-2-methylaniline 6.4 g.
後処理
- filtrationThe reaction mixture was filtered
- concentrationthe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-3499dfe115ea4c8e857bad23413c3625
- 出典データセット
- uspto-grants-2016_04
- 特許番号
- US09314023B2
反応ノート
読み込み中…