化工社化工社 化学情報印刷レポート · 研究参考用
2-Propanethiol → 6-Isopropylsulfanyl-pyridine-2-carboxylic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Propanethiol | HCID 6364 | — |
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | Methyl 6-bromopyridine-2-carboxylate | HCID 16217886 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 6-Isopropylsulfanyl-pyridine-2-carboxylic acid methyl ester | HCID 90118297 | 89.2% |
反応手順
6-Bromo-pyridine-2-carboxylic acid methyl ester (0.15 g, 0.69 mmol) was added with DMF (2.3 mL), Cs2CO3(0.45 g, 1.38 mmol) and 2-propanethiol (0.064 mL, 0.69 mmol) in turn, and the mixture was stirred at room temperature for 18 hours. After the termination of the reaction, the reactant was filtered and concentrated under reduced pressure to obtain the title compound (0.13 g, 88%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09447044B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-792a4140021c4e56b730b7d41a6c301c |
| 出典メモ | uspto-grants-2016_09 |