Methyl 3-chloropyrazine-2-carboxylate → HCID 178499101、化合物

HRID 62863

反応式

HRID 62863 の反応式
[CH3:1][O:2][C:3]([C:5]1[C:10](Cl)=[N:9][CH:8]=[CH:7][N:6]=1)=[O:4].O.[SH-:13].[Na+]>CO>[CH3:1][O:2][C:3]([C:5]1[C:10]([SH:13])=[N:9][CH:8]=[CH:7][N:6]=1)=[O:4]

参加物

4

反応物 2

HCID 1519497Methyl 3-chloropyrazine-2-carboxylateHCID 16211346Sodium hydrosulfide hydrate

生成物 1

HCID 178499101HCID 178499101、化合物収率 89.4%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

After 3-chloro-pyrazine-2-carboxylic acid methyl ester (0.4 g, 2.3 mmol) was dissolved in MeOH (46 mL), sodium hydrosulfide monohydrate (0.65 g, 6.9 mmol) was added thereto, and the mixture was stirred at room temperature for 9 hours. After the termination of the reaction, the reactant was concentrated under reduced pressure, and 1N HCl aqueous solution was used to adjust the pH of the reactant to 3. The reactant was extracted with EtOAc, and the organic layer was separated to obtain the title compound (0.35 g, 89%).

後処理

  1. customAfter the termination of the reaction
  2. concentrationthe reactant was concentrated under reduced pressure, and 1N HCl aqueous solution
  3. extractionThe reactant was extracted with EtOAc
  4. customthe organic layer was separated

出典と根拠

ORDレコード
ord-f1f4215d401d4b258248d4ffd75b3f69
出典データセット
uspto-grants-2016_09
特許番号
US09447044B2

関連ノート

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