Hydrochloric Acid → 2-Isopropylsulfanyl-5-methyl-nicotinic acid

HRID 62875ノート

反応式

HRID 62875 の反応式
[CH:1]([S:4][C:5]1[C:10]([C:11]#N)=[CH:9][C:8]([CH3:13])=[CH:7][N:6]=1)([CH3:3])[CH3:2].[OH-:14].[K+].Cl.[OH2:17]>CS(C)=O>[CH:1]([S:4][C:5]1[N:6]=[CH:7][C:8]([CH3:13])=[CH:9][C:10]=1[C:11]([OH:17])=[O:14])([CH3:3])[CH3:2]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14797Potassium HydroxideHCID 901181222-Isopropylsulfanyl-5-methyl-pyridine-3-carbonitrile

生成物 1

HCID 901181832-Isopropylsulfanyl-5-methyl-nicotinic acid収率 73%

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

反応条件

温度
100 °C

実験手順

After 2-isopropylsulfanyl-5-methyl-pyridine-3-carbonitrile (0.186 g, 0.97 mmol) obtained in Step A was dissolved in water (0.4 mL) and DMSO (0.04 mL), KOH (0.76 g) was added thereto, and the mixture was stirred at 100° C. for 16 hours. After the termination of the reaction, 6N HCl aqueous solution was added thereto to adjust the pH of the reactant to 2, and the mixture was extracted with EtOAc. The organic layer was separated, dried with MgSO4, and concentrated under reduced pressure to obtain the title compound (0.15 g, 73%).

後処理

  1. additionwas added
  2. extractionthe mixture was extracted with EtOAc
  3. customThe organic layer was separated
  4. dry with materialdried with MgSO4
  5. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-3b6193eb6f9940cfa0ee8459627dd774
出典データセット
uspto-grants-2016_09
特許番号
US09447044B2

反応ノート

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