関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 3-Fluoro-p-anisaldehyde | HCID 67696 | — |
| 反応物 | Ethyl 3-(triphenyl-lambda~5~-phosphanylidene)propanoate | HCID 12607919 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | Ethyl 3-(3-fluoro-4-methoxyphenyl)-2-methylprop-2-enoate | HCID 75431686 | 99.5% |
反応手順
After 3-fluoro-4-methoxy-benzaldehyde (0.50 g, 3.24 mmol) was dissolved in anhydrous THF (10 mL), carbethoxyethylidene triphenylphosphorane (1.75 g, 4.86 mmol) was added thereto at 0° C., and the mixture was stirred at room temperature for 3 hours. After the termination of the reaction, the reactant was concentrated under reduced pressure and purified by column chromatography (eluent, EtOAc/Hex=1/2) to obtain the title compound (0.768 g, 99%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09447044B2 |
|---|
| 出典データセット | uspto-grants-2016_09 |
|---|
| ORD ID | ord-1d031625aaf242f59d8c7d4c9fd7f4b5 |
|---|
| 出典メモ | uspto-grants-2016_09 |
|---|
