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4-Toluenesulfonyl chloride → 3-[4-(p-Toluenesulfonyloxy)butyl]-1H-indole-5-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| 反応物 | 3-(4-Hydroxybutyl)-1H-indole-5-carbonitrile | HCID 12150985 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 3-[4-(p-Toluenesulfonyloxy)butyl]-1H-indole-5-carbonitrile | HCID 56952267 | — |
反応手順
3-[4-(p-Toluenesulfonyloxy)butyl]-1H-indole-5-carbonitrile was prepared by reacting 3-(4-hydroxybutyl)-1H-indole-5-carbonitrile with p-toluenesulfonyl chloride in the presence of base in dichloromethane as per the process exemplified in example 2 of Chinese Patent Application Publication No. CN 102267932 A.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09315456B2 |
| 出典データセット | uspto-grants-2016_04 |
| ORD ID | ord-de1fb67b6cc7491288925f091e7cefa9 |
| 出典メモ | uspto-grants-2016_04 |