Methanol → 2-Chloro-6-methoxypyridine-3-carboxylic acid

HRID 62881

反応式

HRID 62881 の反応式
[K].[Cl:2][C:3]1[N:11]=[C:10](Cl)[CH:9]=[CH:8][C:4]=1[C:5]([OH:7])=[O:6].[CH3:13][OH:14]>>[Cl:2][C:3]1[N:11]=[C:10]([O:14][CH3:13])[CH:9]=[CH:8][C:4]=1[C:5]([OH:7])=[O:6]

参加物

4

反応物 3

HCID 887MethanolHCID 8540472,6-Dichloronicotinic acidHCID 5462222Potassium

生成物 1

HCID 117692662-Chloro-6-methoxypyridine-3-carboxylic acid収率 52%

実験手順

Potassium botoxide (483 mg, 4.31 mmol) and MeOH (8 mL) were added to 2,6-dichloro-nicotinic acid (207 mg, 1.07 mmol), and the mixture was stirred using microwave at 60° C. for 1 hour. After the termination of the reaction, the reactant was filtered, and 1N HCl was added thereto at 0° C. to adjust the pH to 3. The solid was dried by N2 gas to obtain the title compound (106 mg, 52%).

後処理

  1. customat 60° C.
  2. customfor 1 hour
  3. customAfter the termination of the reaction
  4. filtrationthe reactant was filtered
  5. addition1N HCl was added
  6. customat 0° C.
  7. dry with materialThe solid was dried by N2 gas

出典と根拠

ORDレコード
ord-8d8eac4a91ad46bab51f5aec9a772f99
出典データセット
uspto-grants-2016_09
特許番号
US09447044B2

関連ノート

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