関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | Bromocyclobutane | HCID 78110 | — |
| 反応物 | HCID 178468955 | HCID 178468955 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 6-Cyclobutylsulfanyl-pyridine-2-carboxylic acid ethyl ester | HCID 90118276 | 93% |
反応手順
After 6-mercapto-pyridine-2-carboxylic acid ethyl ester (0.40 g, 2.18 mmol) was dissolved in CH3CN (9 mL), Cs2CO3(2.667 g, 6.54 mmol) and bromo cyclobutane (0.385 mL, 3.27 mmol) were added thereto, and the mixture was stirred at 50° C. for 18 hours. After the termination of the reaction, the reactant was filtered, concentrated under reduced pressure, and purified by column chromatography (eluent, EtOAc/Hex=1/5) to obtain the title compound (0.481 g, 92%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09447044B2 |
|---|
| 出典データセット | uspto-grants-2016_09 |
|---|
| ORD ID | ord-4a4cf27f8d9946788a2fdf48713ee108 |
|---|
| 出典メモ | uspto-grants-2016_09 |
|---|
