2-Propanethiol → 4-Isopropylsulfanyl-2-methyl-pyrimidine-5-carboxylic acid methyl ester

反応式

[CH3:1][O:2][C:3]([C:5]1[C:6](Cl)=[N:7][C:8]([CH3:11])=[N:9][CH:10]=1)=[O:4].[CH3:13][CH:14]([SH:16])[CH3:15]>>[CH3:1][O:2][C:3]([C:5]1[C:6]([S:16][CH:14]([CH3:15])[CH3:13])=[N:7][C:8]([CH3:11])=[N:9][CH:10]=1)=[O:4]

参加物

反応物 2

HCID 63642-Propanethiol

HCID 83697272Methyl 4-chloro-2-methylpyrimidine-5-carboxylate

生成物 1

HCID 901181774-Isopropylsulfanyl-2-methyl-pyrimidine-5-carboxylic acid methyl ester収率 90%

実験手順

4-Chloro-2-methyl-pyrimidine-5-carboxylic acid methyl ester (0.105 g, 0.56 mmol) and 2-propanethiol were reacted in the same manner as in Step A of Preparation Example 16 to obtain the title compound (0.114 g, 90%).

出典と根拠

ORDレコード: ord-754789530eb34c57855b6617a45abde8
出典データセット: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09447044B2

反応ノート

読み込み中…