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Benzyl Bromide → 4-(Benzyloxy)-2-chlorobenzaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzyl Bromide | HCID 7498 | — |
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | 2-Chloro-4-hydroxybenzaldehyde | HCID 185363 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 4-(Benzyloxy)-2-chlorobenzaldehyde | HCID 14034077 | 59% |
反応手順
2-Chloro-4-hydroxy-benzaldehyde obtained in Step A was dissolved in CH3CN (20 mL). After Cs2CO3(8.7 g, 0.027 mol) was added thereto, benzyl bromide (1.5 mL, 0.013 mol) was added thereto, and the mixture was stirred at room temperature for 2 hours. After the termination of the reaction, the reactant was filtered by using celite, concentrated under reduced pressure, and purified by column chromatography (eluent, EtOAc/Hex=1/5) to obtain the title compound (1.89 g, 59%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09447044B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-558ef29b1e9c468b94748d66fc4d701c |
| 出典メモ | uspto-grants-2016_09 |