Ethyl 6-hydroxyhexanoate → Ethyl 6-((tert-butyldimethylsilyl)oxy)hexanoate

反応式

[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([O:9][CH2:10][CH3:11])=[O:8].[Si:12](OC(CCC)CC(OCC)=O)([C:15]([CH3:18])([CH3:17])[CH3:16])([CH3:14])[CH3:13]>>[Si:12]([O:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([O:9][CH2:10][CH3:11])=[O:8])([C:15]([CH3:18])([CH3:17])[CH3:16])([CH3:14])[CH3:13]

参加物

反応物 2

HCID 357781Ethyl 6-hydroxyhexanoate

HCID 14264095Ethyl 3-((tert-butyldimethylsilyl)oxy)hexanoate

生成物 1

HCID 125473289Ethyl 6-((tert-butyldimethylsilyl)oxy)hexanoate収率 90%

実験手順

Ethyl 6-((tert-butyldimethylsilyl)oxy)hexanoate 8 (3.08 g) was prepared in 90% yield using ethyl 6-hydroxyhexanoate 7 according to the procedures described for compound 2 in above (see Schemes 1-3).

出典と根拠

ORDレコード: ord-33b678d928f24c988ed33f52f0f4cbaa
出典データセット: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09315486B2

反応ノート

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