Morpholine → HCID 86673493、化合物

HRID 629006ノート

反応式

HRID 629006 の反応式
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([O:9][CH2:10][CH3:11])=[CH:4][N:3]=1.[NH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1.[NH4+].[Cl-]>C1(C)C=CC=CC=1>[Cl:1][C:2]1[N:7]=[C:6]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:5]([O:9][CH2:10][CH3:11])=[CH:4][N:3]=1

参加物

5

反応物 3

HCID 8083MorpholineHCID 25517Ammonium ChlorideHCID 155652702,4-Dichloro-5-ethoxypyrimidine

生成物 1

HCID 86673493HCID 86673493、化合物収率 73.5%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒2 回

実験手順

2,4-dichloro-5-ethoxy-pyrimidin (2.83 g, 1.0 eq) was stirred in toluene (20 ml) and a solution of morpholine (1.93 ml, 1.5 eq) in toluene (20 ml) was added dropwise at −10˜0° C. After stirring the resulting solution overnight at r.t., NH4Cl(aq) was added to the solution and the solution was extracted with EA. The combined organic layers were washed with brine, dried and evaporated in vacuo. A product was obtained as a white solid (2.7 g, 73.5%).

後処理

  1. extractionthe solution was extracted with EA
  2. washThe combined organic layers were washed with brine
  3. customdried
  4. customevaporated in vacuo

出典と根拠

ORDレコード
ord-d184133309004e728c3ac474b799dce2
出典データセット
uspto-grants-2016_04
特許番号
US09315491B2

反応ノート

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