Urea → 5-Methoxypyrimidine-2,4,6-triol

HRID 629027

反応式

HRID 629027 の反応式
O(C)[Na].[CH3:4][O:5][CH:6]([C:11]([O:13]C)=O)[C:7]([O:9]C)=O.[NH2:15][C:16]([NH2:18])=[O:17]>CCO>[OH:13][C:11]1[NH:18][C:16](=[O:17])[NH:15][C:7](=[O:9])[C:6]=1[O:5][CH3:4]

参加物

5

反応物 3

HCID 1176UreaHCID 78718Dimethyl methoxymalonateHCID 178418582HCID 178418582、化合物

生成物 1

HCID 673031125-Methoxypyrimidine-2,4,6-triol収率 99%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
100 °C

実験手順

The NaOCH3 (8.5 g, 157 mmole), was added to a stirred solution of dimethyl 2-methoxymalonate (10.2 g, 62.91 mmole), urea (2.5 g, 41.7 mmole), and EtOH (80 ml). The reaction mixture was heated to 100° C. for 4 hrs, then the reaction was evaporated to remove the solvent. Water was added to the mixture and then concentrated HCl was added. The pH of the mixture was adjusted to ca. 3˜4. The mixture was filtered and wash water and acetone. After drying in vacuo, it gave a product (99%).

後処理

  1. customthe reaction was evaporated
  2. customto remove the solvent
  3. additionWater was added to the mixture
  4. additionconcentrated HCl was added
  5. filtrationThe mixture was filtered
  6. washwash water and acetone
  7. customAfter drying in vacuo, it

出典と根拠

ORDレコード
ord-1d949d18dba545aa9d399ca3657db60d
出典データセット
uspto-grants-2016_04
特許番号
US09315491B2

関連ノート

読み込み中…