(Pyrimidin-5-yl)boronic acid → N-(3-Fluoro-4-(trifluoromethoxy)phenyl)-3-(pyrimidin-5-yl)benzamide

HRID 629058

反応式

HRID 629058 の反応式
[F:1][C:2]1[CH:3]=[C:4]([NH:13][C:14](=[O:22])[C:15]2[CH:20]=[CH:19][CH:18]=[C:17](I)[CH:16]=2)[CH:5]=[CH:6][C:7]=1[O:8][C:9]([F:12])([F:11])[F:10].[N:23]1[CH:28]=[C:27](B(O)O)[CH:26]=[N:25][CH:24]=1>>[F:1][C:2]1[CH:3]=[C:4]([NH:13][C:14](=[O:22])[C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:27]3[CH:28]=[N:23][CH:24]=[N:25][CH:26]=3)[CH:16]=2)[CH:5]=[CH:6][C:7]=1[O:8][C:9]([F:12])([F:11])[F:10]

参加物

3

反応物 2

HCID 2795193(Pyrimidin-5-yl)boronic acidHCID 89907118N-(3-fluoro-4-(trifluoromethoxy)phenyl)-3-iodobenzamide

生成物 1

HCID 89907137N-(3-Fluoro-4-(trifluoromethoxy)phenyl)-3-(pyrimidin-5-yl)benzamide

実験手順

The title compound was prepared in an analogous fashion to that described infashion to that described in Example 1 using N-(3-fluoro-4-(trifluoromethoxy)phenyl)-3-iodobenzamide (Stage 9.1) and pyrimidin-5-ylboronic acid to afford the title compound as a white solid. UPLC-MS (Condition 1) tR=2.63 min, m/z=378.0 [M+H]+, m/z=376.1 [M−H]−; 1H-NMR (400 MHz, DMSO-d6) δ ppm 7.56-7.64 (m, 1H) 7.66 (dd, J=9.0, 1.2 Hz, 1H) 7.70-7.76 (m, 1H) 7.97-8.11 (m, 3H) 8.36 (s, 1H) 9.25 (s, 1H) 9.26 (s, 2H) 10.67 (s, 1H).

後処理

  1. customThe title compound was prepared in an analogous fashion to that

出典と根拠

ORDレコード
ord-49dae3715d074633ad88a8500279d6f3
出典データセット
uspto-grants-2016_04
特許番号
US09315489B2

関連ノート

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