3-Iodobenzoic acid → HCID 89907118、化合物

HRID 629059

反応式

HRID 629059 の反応式
[I:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([OH:7])=O.[F:11][C:12]1[CH:13]=[C:14]([CH:16]=[CH:17][C:18]=1[O:19][C:20]([F:23])([F:22])[F:21])[NH2:15]>>[F:11][C:12]1[CH:13]=[C:14]([NH:15][C:5](=[O:7])[C:4]2[CH:8]=[CH:9][CH:10]=[C:2]([I:1])[CH:3]=2)[CH:16]=[CH:17][C:18]=1[O:19][C:20]([F:22])([F:23])[F:21]

参加物

3

反応物 2

HCID 120603-Iodobenzoic acidHCID 194366183-Fluoro-4-(trifluoromethoxy)aniline

生成物 1

HCID 89907118HCID 89907118、化合物

実験手順

The title compound was prepared in an analogous fashion to that described in Stage 30.1 using 3-iodobenzoic acid and 3-fluoro-4-(trifluoromethoxy)aniline to afford the title compound as a white solid. UPLC-MS (Condition 1) tR=3.39 min, m/z=425.9 [M+H]+, m/z=423.9 [M−H]−; 1H-NMR (400 MHz, DMSO-d6) δ ppm 7.32-7.40 (m, 1H) 7.54-7.62 (m, 1H) 7.64 (dd, 1H) 7.93-8.01 (m, 3H) 8.29 (s, 1H) 10.64 (s, 1H).

後処理

  1. customThe title compound was prepared in an analogous fashion to

出典と根拠

ORDレコード
ord-213804908a0c44128c284fa57ce5542d
出典データセット
uspto-grants-2016_04
特許番号
US09315489B2

関連ノート

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