5-Bromo-benzo[b]thiophene-2-carbaldehyde → 5-Butyl-2-formylbenzothiophene

反応式

Br[C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8]([CH:10]=[O:11])=[CH:7][C:6]=2[CH:12]=1.[CH2:13]([B-](F)(F)F)[CH2:14][CH2:15][CH3:16].[K+]>>[CH2:13]([C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8]([CH:10]=[O:11])=[CH:7][C:6]=2[CH:12]=1)[CH2:14][CH2:15][CH3:16]

参加物

反応物 2

HCID 6180355-Bromo-benzo[b]thiophene-2-carbaldehyde

HCID 23693579Potassium Butyltrifluoroborate

生成物 1

HCID 1182289595-Butyl-2-formylbenzothiophene収率 85%

実験手順

The compound was prepared as in Example 3.1 using 5-bromo-2-formylbenzothiophene (241 mg, 1.0 mmol) in place of 5-bromo-2-formylfuran and potassium butyltrifluoroborate (246 mg, 1.5 mmol) in place of hexylboronic acid to give 5-butyl-2-formylbenzothiophene (185 mg, 85%). Used without further characterization.

出典と根拠

ORDレコード: ord-0ad649dbcba6473798dfb99177ece574
出典データセット: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09315495B2

反応ノート

読み込み中…

参加物