5-Bromothiophene-2-carbaldehyde → 5-Pentylthiophene-2-carbaldehyde

反応式

Br[C:2]1[S:6][C:5]([CH:7]=[O:8])=[CH:4][CH:3]=1.[CH2:9](B(O)O)[CH2:10][CH2:11][CH2:12][CH3:13]>>[CH2:9]([C:2]1[S:6][C:5]([CH:7]=[O:8])=[CH:4][CH:3]=1)[CH2:10][CH2:11][CH2:12][CH3:13]

参加物

反応物 2

HCID 784285-Bromothiophene-2-carbaldehyde

HCID 352103Pentylboronic Acid

生成物 1

HCID 139071765-Pentylthiophene-2-carbaldehyde収率 67.4%

実験手順

The compound was synthesized as in Example 3.1 using 5-bromothiophene-2-carbaldehyde (250 mg, 1.31 mmol) in place of 5-bromo-2-formylfuran and pentylboronic acid (250 mg, 2.16 mmol) in place of hexylboronic acid to give 5-pentylthiophene-2-carbaldehyde (161 mg, 67%). Used without further characterization.

出典と根拠

ORDレコード: ord-51c98481b3cc4fd6a902fd98c58090f6
出典データセット: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09315495B2

反応ノート

読み込み中…