Potassium Butyltrifluoroborate → HCID 118228972、化合物

反応式

Br[C:2]1[CH:12]=[CH:11][C:5]2[CH:6]=[C:7]([CH:9]=[O:10])[S:8][C:4]=2[CH:3]=1.[CH2:13]([B-](F)(F)F)[CH2:14][CH2:15][CH3:16].[K+]>>[CH2:13]([C:2]1[CH:12]=[CH:11][C:5]2[CH:6]=[C:7]([CH:9]=[O:10])[S:8][C:4]=2[CH:3]=1)[CH2:14][CH2:15][CH3:16]

参加物

反応物 2

HCID 23693579Potassium Butyltrifluoroborate

HCID 568323096-Bromobenzo[b]thiophene-2-carbaldehyde

生成物 1

HCID 118228972HCID 118228972、化合物収率 85.6%

実験手順

The compound was synthesized as in Example 3.1 using 6-bromobenzothiophene-2-carbaldehyde (110 mg, 0.46 mmol) in place of 5-bromo-2-formylfuran and potassium butyltrifluoroborate (113 mg, 0.69 mmol) in place of hexylboronic acid to give 6-butylbenzothiophene-2-carbaldehyde (86 mg, 78%). Used without further characterization.

出典と根拠

ORDレコード: ord-a10f8938f6d14aba9c21514ed39a5f30
出典データセット: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09315495B2

反応ノート

読み込み中…