5-Bromo-1H-indole-2-carbaldehyde → 5-butyl-1H-indole-2-carbaldehyde

反応式

Br[C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([CH:11]=[O:12])=[CH:5]2.[CH2:13]([B-](F)(F)F)[CH2:14][CH2:15][CH3:16].[K+]>>[CH2:13]([C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([CH:11]=[O:12])=[CH:5]2)[CH2:14][CH2:15][CH3:16]

参加物

反応物 2

HCID 135224625-Bromo-1H-indole-2-carbaldehyde

HCID 23693579Potassium Butyltrifluoroborate

生成物 1

HCID 1182227845-butyl-1H-indole-2-carbaldehyde収率 28%

実験手順

5-Butyl-1H-indole-2-carbaldehyde was synthesized as in Example 3.1 using 5-bromo-1H-indole-2-carbaldehyde (300 mg, 1.34 mmol) in place of 5-bromo-2-formylfuran and potassium butyltrifluoroborate (352 mg, 2.21 mmol) in place of hexylboronic acid to give 5-butyl-1H-indole-2-carbaldehyde (75 mg, 28%). Used without further characterization.

出典と根拠

ORDレコード: ord-8969cf2de75e43a9ac7c4bbf7d30c1b7
出典データセット: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09315495B2

反応ノート

読み込み中…

参加物