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Ethyl 3-(4-hydroxyphenyl)-2-methylpropanoate → 3-[4-(2-Isopropylsulfanyl-pyridin-3-ylmethoxy)-phenyl]-2-methyl-propionic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl 3-(4-hydroxyphenyl)-2-methylpropanoate | HCID 20748401 | — |
| 反応物 | 3-Chloromethyl-2-isopropylsulfanyl-pyridine | HCID 53816681 | — |
| 生成物 | 3-[4-(2-Isopropylsulfanyl-pyridin-3-ylmethoxy)-phenyl]-2-methyl-propionic acid ethyl ester | HCID 90118201 | 53.5% |
反応手順
3-Chloromethyl-2-isopropylsulfanyl-pyridine (0.063 g, 0.31 mmol) obtained in Step C of Preparation Example 1 and 3-(4-hydroxy-phenyl)-2-methyl-propionic acid ethyl ester (0.065 g, 0.31 mmol) obtained in Step B of Preparation Example 3 were reacted in the same manner as in Step A of Example 1 to obtain the title compound (0.062 g, 53%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09447044B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-5bf84665a5bb4ea2846f25921390c4cc |
| 出典メモ | uspto-grants-2016_09 |