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HRID 62923作成日:2026年10月26日

Benzenepropanoic acid, 4-hydroxy-, methyl ester → 3-[4-(2-Isopropylsulfanyl-5-methyl-pyridin-3-ylmethoxy)-phenyl]-propionic acid

https://huagongshe.com/reaction/62923

反応式

関与物質

役割名称HCID仕込み量
反応物Benzenepropanoic acid, 4-hydroxy-, methyl esterHCID 79706—
反応物3-Chloromethyl-2-isopropylsulfanyl-5-methyl-pyridineHCID 90118277—
生成物3-[4-(2-Isopropylsulfanyl-5-methyl-pyridin-3-ylmethoxy)-phenyl]-propionic acidHCID 7422219955%

反応手順

3-Chloromethyl-2-isopropylsulfanyl-5-methyl-pyridine (0.052 g, 0.24 mmol) obtained in Step D of Preparation Example 30 and 3-(4-hydroxy-phenyl)-propionic acid methyl ester (0.043 g, 0.24 mol) obtained in Preparation Example 4 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (55%).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09447044B2
出典データセットuspto-grants-2016_09
ORD IDord-4a89aa6084f246eeb05445ac6e85f153
出典メモuspto-grants-2016_09