化工社化工社 化学情報印刷レポート · 研究参考用
Ethyl 3-(3,5-difluoro-4-hydroxyphenyl)propanoate → 3-[3,5-Difluoro-4-(2-isopropylsulfanyl-6-methyl-pyridin-3-ylmethoxy)-phenyl]-propionic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl 3-(3,5-difluoro-4-hydroxyphenyl)propanoate | HCID 23136305 | — |
| 反応物 | 3-Chloromethyl-2-isopropylsulfanyl-6-methyl-pyridine | HCID 90118198 | — |
| 生成物 | 3-[3,5-Difluoro-4-(2-isopropylsulfanyl-6-methyl-pyridin-3-ylmethoxy)-phenyl]-propionic acid | HCID 74222280 | 78% |
反応手順
3-Chloromethyl-2-isopropylsulfanyl-6-methyl-pyridine obtained in Step D of Preparation Example 9 and 3-(3,5-difluoro-4-hydroxy-phenyl)-propionic acid ethyl ester (236 mg, 1.02 mmol) obtained in Step D of Preparation Example 2 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (278 mg, 78%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09447044B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-8f581ce507d44acf9e27e7a7e7f635a4 |
| 出典メモ | uspto-grants-2016_09 |