Ethyl 3-(3,5-difluoro-4-hydroxyphenyl)propanoate → HCID 74222281、化合物

HRID 62925

反応式

HRID 62925 の反応式
[CH2:1]([S:5][C:6]1[C:11]([CH2:12]Cl)=[CH:10][CH:9]=[CH:8][N:7]=1)[CH2:2]CC.C([O:16][C:17](=[O:29])[CH2:18][CH2:19][C:20]1[CH:25]=[C:24]([F:26])[C:23]([OH:27])=[C:22]([F:28])[CH:21]=1)C>>[CH2:1]([S:5][C:6]1[C:11]([CH2:12][O:27][C:23]2[C:22]([F:28])=[CH:21][C:20]([CH2:19][CH2:18][C:17]([OH:29])=[O:16])=[CH:25][C:24]=2[F:26])=[CH:10][CH:9]=[CH:8][N:7]=1)[CH3:2]

参加物

3

反応物 2

HCID 23136305Ethyl 3-(3,5-difluoro-4-hydroxyphenyl)propanoateHCID 901182542-Butylsulfanyl-3-chloromethyl-pyridine

生成物 1

HCID 74222281HCID 74222281、化合物収率 76%

実験手順

3-Chloromethyl-2-ethylsulfanyl-pyridine (0.1 g, 0.53 mmol) obtained in Step C of Preparation Example 11 and 3-(3,5-difluoro-4-hydroxy-phenyl)-propionic acid ethyl ester (0.12 g, 0.53 mmol) obtained in Step D of Preparation Example 2 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (76% yield).

後処理

  1. customto react sequentially in the same manner as in Steps A and B of Example 1

出典と根拠

ORDレコード
ord-d8ceb9879ce342de806ce711e0c7be7b
出典データセット
uspto-grants-2016_09
特許番号
US09447044B2

関連ノート

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