4-(Methanesulfonyl)phenylboronic acid → 6-Bromo-3-(4-methanesulfonyl-phenyl)-imidazo[1,2-a]pyridine
反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8](I)=[CH:9][N:10]=2)[CH:7]=1.[CH3:12][S:13]([C:16]1[CH:21]=[CH:20][C:19](B(O)O)=[CH:18][CH:17]=1)(=[O:15])=[O:14]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([C:19]3[CH:20]=[CH:21][C:16]([S:13]([CH3:12])(=[O:15])=[O:14])=[CH:17][CH:18]=3)=[CH:9][N:10]=2)[CH:7]=1参加物
3
実験手順
The title compound, brown solid (0.53 g, 69%), MS (ISP) m/z=353.4 [(M+H)+], mp 194° C., was prepared in accordance with the general method of intermediate E from commercially available 6-bromo-3-iodoimidazo[1,2-a]pyridine (0.7 g, 2.17 mmol) and commercially available 4-methanesulfonyl-phenylboronic acid (0.48 g, 2.38 mmol).
出典と根拠
- ORDレコード
- ord-f2cd2c9e0ed84b479ce0291987f6e834
- 出典データセット
- uspto-grants-2016_04
- 特許番号
- US09315502B2
反応ノート
読み込み中…