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3-Chloromethyl-2-phenylsulfanyl-pyridine → 3-[3,5-Difluoro-4-(2-phenylsulfanyl-pyridin-3-ylmethoxy)-phenyl]-propionic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Chloromethyl-2-phenylsulfanyl-pyridine | HCID 19261865 | — |
| 反応物 | Ethyl 3-(3,5-difluoro-4-hydroxyphenyl)propanoate | HCID 23136305 | — |
| 生成物 | 3-[3,5-Difluoro-4-(2-phenylsulfanyl-pyridin-3-ylmethoxy)-phenyl]-propionic acid | HCID 74222286 | 51% |
反応手順
3-Chloromethyl-2-phenylsulfanyl-pyridine obtained in Step C of Preparation Example 15 and 3-(3,5-difluoro-4-hydroxy-phenyl)-propionic acid ethyl ester (21 mg, 0.09 mmol) obtained in Step D of Preparation Example 2 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (19 mg, 51%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09447044B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-46d8dd121b6d408cab4191cbe4855496 |
| 出典メモ | uspto-grants-2016_09 |