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Ethyl 3-(3,5-difluoro-4-hydroxyphenyl)propanoate → 3-[4-(2-t-Butylsulfanyl-pyridin-3-ylmethoxy)-3,5-difluoro-phenyl]-propionic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl 3-(3,5-difluoro-4-hydroxyphenyl)propanoate | HCID 23136305 | — |
| 反応物 | 2-t-Butylsulfanyl-3-chloromethyl-pyridine | HCID 90118202 | — |
| 生成物 | 3-[4-(2-t-Butylsulfanyl-pyridin-3-ylmethoxy)-3,5-difluoro-phenyl]-propionic acid ethyl ester | HCID 90118671 | 86% |
反応手順
2-t-Butylsulfanyl-3-chloromethyl-pyridine (0.08 g, 0.37 mmol) obtained in Step C of Preparation Example 17 and 3-(3,5-difluoro-4-hydroxy-phenyl)-propionic acid ethyl ester obtained in Step D of Preparation Example 2 were used to react in the same manner as in Step A of Example 1 to obtain the title compound (0.13 g, 86%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09447044B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-867258840b3d4f1691395980e6e92a31 |
| 出典メモ | uspto-grants-2016_09 |