Water → 5-bromo-2-hydroxy-4-methylbenzoic acid

HRID 629330ノート

反応式

HRID 629330 の反応式
[OH:1][C:2]1[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[Br:12]Br.O>C(O)(=O)C>[Br:12][C:8]1[C:9]([CH3:11])=[CH:10][C:2]([OH:1])=[C:3]([CH:7]=1)[C:4]([OH:6])=[O:5]

参加物

5

反応物 3

HCID 962WaterHCID 57882-Hydroxy-p-toluic acidHCID 24408Bromine

生成物 1

HCID 2439345-bromo-2-hydroxy-4-methylbenzoic acid

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

To a solution of 2-hydroxy-4-methylbenzoic acid (5.00 g) in acetic acid (70.0 mL) was added dropwise bromine (1.68 mL), and the mixture was stirred at room temperature for 5.5 hr. To the reaction mixture was added water, and the precipitate was collected by filtration, and dried under reduced pressure to give the title compound (6.78 g).

後処理

  1. filtrationthe precipitate was collected by filtration
  2. customdried under reduced pressure

出典と根拠

ORDレコード
ord-33f50400cbf0496d9ad10fd87bd16de3
出典データセット
uspto-grants-2016_04
特許番号
US09315458B2

反応ノート

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