Potassium Carbonate → Methyl 3-chloro-2-hydroxy-4-(trifluoromethyl)benzoate

HRID 629356ノート

反応式

HRID 629356 の反応式
[Cl:1][C:2]1[C:3]([O:16]C(OC)=O)=[C:4]([CH:9]=[CH:10][C:11]=1[C:12]([F:15])([F:14])[F:13])[C:5]([O:7][CH3:8])=[O:6].C(=O)([O-])[O-].[K+].[K+]>CO>[Cl:1][C:2]1[C:3]([OH:16])=[C:4]([CH:9]=[CH:10][C:11]=1[C:12]([F:14])([F:15])[F:13])[C:5]([O:7][CH3:8])=[O:6]

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 118468126Methyl 3-chloro-2-[(methoxycarbonyl)oxy]-4-(trifluoromethyl)benzoate

生成物 1

HCID 118468129Methyl 3-chloro-2-hydroxy-4-(trifluoromethyl)benzoate収率 71.6%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
15 °C

実験手順

To a solution of methyl 3-chloro-2-[(methoxycarbonyl)oxy]-4-(trifluoromethyl)benzoate (6.00 g) in methanol (60.0 mL) was added potassium carbonate (8.00 g), and the mixture was stirred at 15° C. for 16 hr. The reaction mixture was filtered, the filtrate was neutralized with 1N hydrochloric acid, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (3.50 g).

後処理

  1. filtrationThe reaction mixture was filtered
  2. extractionthe mixture was extracted with ethyl acetate
  3. washThe organic layer was washed with saturated brine
  4. dry with materialdried over anhydrous sodium sulfate
  5. customthe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-5d83b9ed898f4d198237d5fd7d22ea48
出典データセット
uspto-grants-2016_04
特許番号
US09315458B2

反応ノート

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