Water → 5-Bromo-3-chloro-2-hydroxy-4-methoxybenzoic acid
反応式
[Cl:1][C:2]1[C:3]([OH:13])=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][CH3:12])[C:5]([OH:7])=[O:6].[Br:14]Br.O>C(O)(=O)C>[Br:14][C:9]1[C:10]([O:11][CH3:12])=[C:2]([Cl:1])[C:3]([OH:13])=[C:4]([CH:8]=1)[C:5]([OH:7])=[O:6]参加物
5
実験手順
To a solution of 3-chloro-2-hydroxy-4-methoxybenzoic acid (11.1 g) in acetic acid (275 mL) was added bromine (8.79 g) at room temperature, and the mixture was stirred for 16 hr. To the reaction mixture was added water, and the precipitate was collected by filtration. The precipitate was washed with water, and dissolved in ethyl acetate, and the solution was washed with water and saturated brine. The organic layer was dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (10.4 g).
後処理
- filtrationthe precipitate was collected by filtration
- washThe precipitate was washed with water
- dissolutiondissolved in ethyl acetate
- washthe solution was washed with water and saturated brine
- dry with materialThe organic layer was dried over anhydrous sodium sulfate
- customthe solvent was evaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-c0169a4f5e5149f38c2f2c304e110a3b
- 出典データセット
- uspto-grants-2016_04
- 特許番号
- US09315458B2
反応ノート
読み込み中…