2-Hydroxy-4-vinyl-benzoic acid methyl ester → Methyl 4-ethyl-2-hydroxybenzoate

HRID 629470ノート

反応式

HRID 629470 の反応式
[OH:1][C:2]1[CH:11]=[C:10]([CH:12]=[CH2:13])[CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5]>C(O)C.[C].[Pd]>[CH2:12]([C:10]1[CH:9]=[CH:8][C:3]([C:4]([O:6][CH3:7])=[O:5])=[C:2]([OH:1])[CH:11]=1)[CH3:13]

参加物

4

反応物 1

HCID 200893762-Hydroxy-4-vinyl-benzoic acid methyl ester

生成物 1

HCID 54092218Methyl 4-ethyl-2-hydroxybenzoate収率 61.2%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 702Ethanol溶媒

実験手順

To a solution of methyl 2-hydroxy-4-vinylbenzoate (2.31 g) in ethanol (25.0 mL) was added palladium-carbon (1.38 g), and the mixture was stirred overnight at room temperature under hydrogen atmosphere. The insoluble substance was removed by filtration, and the filtrate was concentrated under reduced pressure. The obtained residue was purified by NH silica gel column chromatography (ethyl acetate/hexane) to give the title compound (1.43 g).

後処理

  1. customThe insoluble substance was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customThe obtained residue was purified by NH silica gel column chromatography (ethyl acetate/hexane)

出典と根拠

ORDレコード
ord-dbf89bd7c938424387e80510ea411f7a
出典データセット
uspto-grants-2016_04
特許番号
US09315458B2

反応ノート

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