Water → Methyl 5-bromo-4-ethyl-2-hydroxybenzoate

HRID 629471ノート

反応式

HRID 629471 の反応式
[CH2:1]([C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[C:5]([OH:13])[CH:4]=1)[CH3:2].[Br:14]Br.O>C(O)(=O)C>[Br:14][C:12]1[C:3]([CH2:1][CH3:2])=[CH:4][C:5]([OH:13])=[C:6]([CH:11]=1)[C:7]([O:9][CH3:10])=[O:8]

参加物

5

反応物 3

HCID 962WaterHCID 24408BromineHCID 54092218Methyl 4-ethyl-2-hydroxybenzoate

生成物 1

HCID 118468133Methyl 5-bromo-4-ethyl-2-hydroxybenzoate収率 107.5%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

To a solution of methyl 4-ethyl-2-hydroxybenzoate (1.43 g) in acetic acid (15.0 mL) was added bromine (1.40 g) under ice-cooling, and the mixture was stirred at room temperature for 2 hr under argon atmosphere. To the reaction mixture was added water, the resulting solid was collected by filtration, and dried under reduced pressure to give the title compound (2.21 g) as a mixture with methyl 3,5-dibromo-4-ethyl-2-hydroxybenzoate (2:1). This compound was used in the next step without an additional purification.

後処理

  1. temperaturecooling
  2. filtrationthe resulting solid was collected by filtration
  3. customdried under reduced pressure

出典と根拠

ORDレコード
ord-e74eab0a62dc4172aace3357622e9356
出典データセット
uspto-grants-2016_04
特許番号
US09315458B2

反応ノート

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