3-(4-Hydroxyphenyl)-2,2-dimethylpropanoic acid ethyl ester → 3-[4-(6-Isopropylsulfanyl-pyridin-2-ylmethoxy)-phenyl]-2,2-dimethyl-propionic acid

HRID 62949ノート

反応式

HRID 62949 の反応式
Cl[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([S:9][CH:10]([CH3:12])[CH3:11])[N:4]=1.C([O:15][C:16](=[O:28])[C:17]([CH3:27])([CH3:26])[CH2:18][C:19]1[CH:24]=[CH:23][C:22]([OH:25])=[CH:21][CH:20]=1)C>>[CH:10]([S:9][C:5]1[N:4]=[C:3]([CH2:2][O:25][C:22]2[CH:21]=[CH:20][C:19]([CH2:18][C:17]([CH3:27])([CH3:26])[C:16]([OH:28])=[O:15])=[CH:24][CH:23]=2)[CH:8]=[CH:7][CH:6]=1)([CH3:12])[CH3:11]

参加物

3

反応物 2

HCID 461805253-(4-Hydroxyphenyl)-2,2-dimethylpropanoic acid ethyl esterHCID 901181412-Chloromethyl-6-isopropylsulfanyl-pyridine

生成物 1

HCID 742227043-[4-(6-Isopropylsulfanyl-pyridin-2-ylmethoxy)-phenyl]-2,2-dimethyl-propionic acid収率 81.5%

実験手順

2-Chloromethyl-6-isopropylsulfanyl-pyridine (0.02 g, 0.099 mmol) obtained in Step C of Preparation Example 16 and 3-(4-hydroxy-phenyl)-2,2-dimethyl-propionic acid ethyl ester (0.022 g, 0.099 mmol) obtained in Step D of Preparation Example 39 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (0.029 g, 81%).

後処理

  1. customto react sequentially in the same manner as in Steps A and B of Example 1

出典と根拠

ORDレコード
ord-b8f8e271e2f047058d7882abc13f8455
出典データセット
uspto-grants-2016_09
特許番号
US09447044B2

反応ノート

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